The Scientific Foundation

The scientific foundation
behind
Cell Boost and Balance – CellBB

Explore the research, clinical expertise, and formulation details that make CellBB Immune Equilibrium a scientifically designed immune support solution.

Immune Equilibrium

Created by Nature, Enhanced by Science​

CellBB’s foundation lies in groundbreaking scientific research, specifically the discovery of Bio-Active Phospholipids (BAP™)in fertilized eggs. This unique phospholipid complex supports healthy development from a single cell to a complete organism. Inspired by nature,CellBB harnesses the power of BAP™using only natural ingredients, free from artificial additives, to promote optimal cellular function and overall well-being.

  • CellBB is animal based unlike most phospholipid (PL) supplements on the market which are plant-based.
  • The plant-based blends are missing some PLs essential for our healthy cell function.
  • CellBB PLs extracted from eggs are isolated to match the life-supporting mixture in the early development of chick embryos.
  • CellBB egg proteins are removed while leaving the BAPs essential to healthy cell function.

The Discovery of Bio-Active Phospholipids (BAP)

Lab discovery – early research

The groundbreaking journey of CellBB began with a remarkable scientific discovery at the Czechoslovak Academy of Sciences.

Led by Dr. J. Kara, researchers uncovered a unique mixture of phospholipids in fertilized eggs that showed significantly different properties compared with those in unfertilized eggs.

This breakthrough opened the door to understanding a special class of bio-active phospholipids that support healthy cell function.

Production and scientific collaboration

This pivotal finding sparked a collaboration between Areko, a dietary supplement manufacturer in Prague, Czech Republic, and renowned scientists, including Dr. J. Kara and Dr. A. Novacek.

Their combined expertise led to the development of a pioneering product based on these specialized phospholipids, laying the scientific foundation behind today’s CellBB formulations.

Modern production – Ovosan / CellBB

In 1998, Areko introduced Ovosan to the market, marking the beginning of a new era in cellular health supplementation.

This innovative product laid the groundwork for the advanced formulation we now know as CellBB, which continues to build on this original, groundbreaking research into Bio-Active Phospholipids (BAP).

What is a phospholipid?

Phospholipids (PLs) are specialized fats that serve as essential building blocks of cellular membranes throughout the body. These remarkable molecules surround every cell and its organelles, while also functioning as vital signaling molecules that enable cellular communication and control of critical biological processes.

Phospholipid bilayer

Phospholipid bilayer

The foundation of a cell membrane.

Cell Membrane

Cell Membrane

Phospholipids are the key components.

Phospholipid detail

Phospholipid detail

A basic make up of a phospholipid used in our body.

Phospholipids

Phospholipids

Various structures that can be formed by phospholipids.

What are the Unique Properties and Benefits of Bio-Active Phospholipids (BAP™) and how they differ from PLs in regular eggs?

Percentage of Normalized Immune Response
1
Control W/O BAP
80
Bio-active PLs (BAP)
1
Raw PLs
(Illustrative comparison based on normalized immune response)

BAP™ represents a breakthrough in cellular health, matching the precise composition found in fertilized eggs. During early embryonic development, this unique phospholipid complex plays a crucial role in cellular regulation and repair.

Unlike raw egg yolks or other phospholipid supplements on the market, CellBB’s proprietary BAP™ formulation enhances the immune response. This is shown in the chart with the normalized immune response that was measured by a tumor size reduction and immunity enhancement, and compared to regular raw egg phospholipids (not purified to match fertilized egg) and a control (sunflower oil only).

The unique BAP™ composition in CellBB demonstrates significant biological effects that are not found in regular phospholipid mixtures or raw eggs, making it a truly innovative approach to cellular health support.

Benefits of BAP™

BAP icon Phospholipid composition inspired by nature

Natural phospholipids extracted from egg yolks to match the early stages of embryonic development.

A unique composition that closely matches our own cellular membranes and plays a vital role in cellular health.

No artificial ingredients or proteins, with the potential for reduced allergic reaction.

Phospholipid detail

  1. 01

    The cell membrane is essential for life, as it regulates the flow of information and materials in and out of the cell.

  2. 02

    Phospholipids form the cell membrane’s backbone, creating a selectively permeable barrier which allows the cell to communicate and interact with other cells and molecules.

  3. 03

    The cell membrane protects against pathogens, facilitates chemical processes, and allows nutrients in and waste out.

  4. 04

    Key phospholipids include phosphatidylcholine (PC), phosphatidylethanolamine (PE) and sphingolipids like sphingomyelin (SM).

  5. 05

    CellBB contains these essential phospholipids in effective liposomal form.

Cell membrane illustration
Protect Organelles

Protect Organelles (Organs of the Cell)

  • Phospholipids are found in all membranes surrounding cell organelles, including mitochondria (energy producers), the endoplasmic reticulum (protein folding and transport) and the nucleus. The nucleus is the command center of the cell housing the DNA.
  • Protecting these organelles is vital for cellular function and overall vitality.
Support Brain Health

Support Brain Health

  • Phospholipids contribute to brain health by maintaining cell membranes and supporting neurotransmitter function.
  • Phosphatidyl choline (PC) is an important source of choline for the neurotransmitter Acetylcholine.
Support Mitochondrial Function

Support Mitochondrial Function

  • Phospholipids form the outer and inner membranes of mitochondria, giving them their characteristic shape.
  • Phospholipids in mitochondria are not only structural components but also active participants in energy production, signaling and cellular communication.
  • Their intricate roles underscore the importance of these lipid molecules in maintaining cellular vitality.

Healthy cell phospholipid membranes are associated with longevity.

This was recently discussed in a scientific article published in Nature. Read a brief summary of the findings on our blog!

focuses on keeping the cellular membranes and cells as healthy as possible.†
Smiling patient and caregiver discussing healthy cell phospholipid membranes
Phospholipids and immune cells

Phospholipids in CellBB activate NK cells of the immune system

Antibodies icon

NK cells have shown increased activity in attacking antigens

CellBB boosts NK cells and innate immunity

Shield icon

The activation of NK cells can suppress the adaptive immune system, such as T-cells

Natural Killer (NK) cells play a crucial role in maintaining immune system balance. These specialized cells act as vigilant guardians, defending against external threats while helping regulate immune responses to prevent overreaction. This delicate balance is essential for protecting against infections and abnormal cells while preventing autoimmune responses and allergic reactions that could harm healthy tissue.

NK cell activity illustration 1

NK cells exposed to BAP formulation have shown increased activity in attacking antigens, such as cancer cells, viruses and bacteria.

NK cell activity illustration 2

The activation was also confirmed in NK cells that were taken away from animals previously dosed with BAP formulation.

NK cell activity illustration 3

The activation of NK cells can contribute to suppression of immune attack by the adaptive immune system, such as T-cells.

Liposomes – delivery to
where it’s needed

01

The liposomes are essential in maintaining the stability of the BAP composition throughout digestion and reaching the vital organs and individual cells.

02

For example, we have found that our liposomes are delivered to the brain, lungs, tumors and the liver in mice.

CellBB utilizes liposome nanoparticles to deliver the bioactive phospholipids to the body’s cells. Nanoparticles are tiny particles that can cross biological barriers and increase the bioavailability of the substances they carry.

Liposomal nanoparticles accumulate in the liver and tissues with high nutrient demand. For example, liposomes could accumulate in areas with damaged tissue after injury.

Liposome structure illustration

Experience with BAP and Ovosan – a supplement
distributed by Areko in Europe

100s of thousands of customers

25 years of safety and satisfaction experience

CellBB brings the health benefits of Ovosan
and BAP to the US for the first time

Experience with BAP and Ovosan – Team

CellBB: A Breakthrough in Cellular Health Now Available in the United States

After more than two decades of proven success in Europe through Ovosan, this revolutionary cellular health supplement is now accessible to U.S. consumers as CellBB. Through Immod’s strategic collaboration with Machavert and the prestigious University of Colorado’s Anschutz Medical Campus, alongside European pioneer Areko, we’ve optimized this groundbreaking formula for the American market.

This powerful alliance combines decades of European clinical experience with cutting-edge American research to deliver an exceptional supplement that supports cellular vitality and immune function. CellBB's unique Bio-Active Phospholipid (BAP™) formulation represents the culmination of extensive scientific research and real-world application, offering Americans access to a supplement with a proven track record of supporting optimal cellular health and overall wellness.

Experience the science-backed benefits that European consumers have trusted for over 20 years, now enhanced through advanced research and development for the U.S. market.

Powerful Anti-Inflammatory Properties of BAP™

Scientific research has demonstrated the remarkable anti-inflammatory capabilities of Bio-Active Phospholipids (BAP™) in advanced medical studies. In a groundbreaking investigation using porcine models with severe bacterial pneumonia, BAP™ showed exceptional healing properties. The results were striking: 60% of infected lungs achieved complete recovery, while the remaining 40% showed significant improvement, with an overall reduction in inflammatory lesions of 89%.

Initially attributed to unspecified immune effects, subsequent research revealed that this powerful anti-inflammatory response stems from BAP's unique ability to activate Natural Killer (NK) cells. This discovery highlights BAP's fundamental role in supporting the body's natural immune response and inflammatory regulation mechanisms.

BAP's Impact on Pig Pneumonia
After 14 Days

Lung Tissue Damage Percentage

89% reduction
36
4
Control W/O BAP Bio-active PLs (BAP)

Additional Preclinical Research Findings

Extensive preclinical research has demonstrated BAP’s significant anti-cancer properties, with studies showing these effects are primarily driven through immune system activation. The research revealed that beneficial anti-cancer outcomes were specifically observed in subjects maintaining at least partial immune system function, highlighting the crucial relationship between BAP’s effectiveness and immune system competency.

Clinical Experience with Ovosan and BAP – CellBB's Active Ingredient

Clinical experience image A

BAP™ has demonstrated significant benefits in supporting cancer patients through chemotherapy, helping to maintain quality of life and cellular health during treatment. This support extends beyond the treatment phase, assisting in recovery and ongoing wellness.

Clinical experience image B

Additionally, extensive clinical experience has shown notable results in dermatological applications and immune system modulation, highlighting BAP’s versatility in supporting overall health and cellular function.

The discovery of the immuno-modulating phospholipid

Groundbreaking Research at Machavert

Scientists at Machavert and CU Anschutz validated previous findings by Areko regarding BAP’s effectiveness.

A key breakthrough occurred with the isolation of GPC-182, a specific bio-active phospholipid from Ovosan, leading to the formulation of MPI115, the key component of CellBB.

Research revealed MPI115's ability to:

Activate Natural Killer (NK) cells within the innate immune system

Enhance NK cell activity against cancer cells

Increase interferon-gamma secretion

Demonstrate significant anti-cancer activity in animal studies, directly linked to NK cell activation

Show immuno-suppressive properties through T-cells modulation

These findings provided scientific validation for Areko's earlier observations and research results.

Future Direction

The research team aims to expand clinical evidence for CellBB and Ovosan while deepening the understanding of their benefits to develop a comprehensive roadmap for potential applications.